High‐frequency unilateral thalamic stimulation in the treatment of essential and parkinsonian tremor
Identifieur interne : 001015 ( Main/Corpus ); précédent : 001014; suivant : 001016High‐frequency unilateral thalamic stimulation in the treatment of essential and parkinsonian tremor
Auteurs : Koller ; Rajesh Pahwa ; Karen Busenbark ; Jean Hubble ; Steve Wilkinson ; Anthony Lang ; Paul Tuite ; Elspeth Sime ; Andres Lazano ; Robert Hauser ; Teresita Malapira ; Donald Smith ; Daniel Tarsy ; Edison Miyawaki ; Thorkild Norregaard ; Theresa Kormos ; C. Warren OlanowSource :
- Annals of Neurology [ 0364-5134 ] ; 1997-09.
Abstract
Pharmacologic treatment for essential tremor and the tremor of Parkinson's disease is often inadequate. Stereotaxic surgery, such as thalamotomy, can effectively reduce tremors. We performed a multicenter trial of unilateral high‐frequency stimulation of the ventral intermedius nucleus of the thalamus in 29 patients with essential tremor and 24 patients with Parkinson's disease, using a blinded assessment at 3 months after surgery to compare clinical rating of tremor with stimulation ON with stimulation OFF and baseline and a 1‐year follow‐up. Six patients were not implanted because of lack of intraoperative tremor suppression (2 patients), hemorrhage (2 patients), withdrawal of consent (1 patient), and persistent microthalamotomy effect (1 patient). A significant reduction in both essential and parkinsonian tremor occurred contralaterally with stimulation. Patients reported a significant reduction in disability. Measures of function were significantly improved in patients with essential tremor. Complications related to surgery in implanted patients were few. Stimulation was commonly associated with transient paresthesias. Other adverse effects were mild and well tolerated. Efficacy was not reduced at 1 year. Chronic high‐frequency stimulation is safe and highly effective in ameliorating essential and parkinsonian tremor.
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DOI: 10.1002/ana.410420304
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<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">High‐frequency unilateral thalamic stimulation in the treatment of essential and parkinsonian tremor</title><author><name sortKey="Koller" sort="Koller" uniqKey="Koller" last="Koller">Koller</name><affiliation><mods:affiliation>Department of Neurology, University of Kansas Medical Center, Kansas City, KS</mods:affiliation></affiliation></author><author><name sortKey="Pahwa, Rajesh" sort="Pahwa, Rajesh" uniqKey="Pahwa R" first="Rajesh" last="Pahwa">Rajesh Pahwa</name><affiliation><mods:affiliation>Department of Neurology, University of Kansas Medical Center, Kansas City, KS</mods:affiliation></affiliation></author><author><name sortKey="Busenbark, Karen" sort="Busenbark, Karen" uniqKey="Busenbark K" first="Karen" last="Busenbark">Karen Busenbark</name><affiliation><mods:affiliation>Department of Neurology, University of Kansas Medical Center, Kansas City, KS</mods:affiliation></affiliation></author><author><name sortKey="Hubble, Jean" sort="Hubble, Jean" uniqKey="Hubble J" first="Jean" last="Hubble">Jean Hubble</name><affiliation><mods:affiliation>Department of Neurology, Ohio State University Hospitals, Columbus, OH</mods:affiliation></affiliation></author><author><name sortKey="Wilkinson, Steve" sort="Wilkinson, Steve" uniqKey="Wilkinson S" first="Steve" last="Wilkinson">Steve Wilkinson</name><affiliation><mods:affiliation>Department of Neurosurgery, University of Kansas Medical Center, Kansas City, KS</mods:affiliation></affiliation></author><author><name sortKey="Lang, Anthony" sort="Lang, Anthony" uniqKey="Lang A" first="Anthony" last="Lang">Anthony Lang</name><affiliation><mods:affiliation>Division of Neurology, Toronto Hospital, Toronto, Ontario, Canada</mods:affiliation></affiliation></author><author><name sortKey="Tuite, Paul" sort="Tuite, Paul" uniqKey="Tuite P" first="Paul" last="Tuite">Paul Tuite</name><affiliation><mods:affiliation>Division of Neurology, Toronto Hospital, Toronto, Ontario, Canada</mods:affiliation></affiliation></author><author><name sortKey="Sime, Elspeth" sort="Sime, Elspeth" uniqKey="Sime E" first="Elspeth" last="Sime">Elspeth Sime</name><affiliation><mods:affiliation>Division of Neurology, Toronto Hospital, Toronto, Ontario, Canada</mods:affiliation></affiliation></author><author><name sortKey="Lazano, Andres" sort="Lazano, Andres" uniqKey="Lazano A" first="Andres" last="Lazano">Andres Lazano</name><affiliation><mods:affiliation>Division of Neurosurgery, Toronto Hospital, Toronto, Ontario, Canada</mods:affiliation></affiliation></author><author><name sortKey="Hauser, Robert" sort="Hauser, Robert" uniqKey="Hauser R" first="Robert" last="Hauser">Robert Hauser</name><affiliation><mods:affiliation>Parkinson's Disease and Movement Disorders Center, University of South Florida, Tampa, FL</mods:affiliation></affiliation></author><author><name sortKey="Malapira, Teresita" sort="Malapira, Teresita" uniqKey="Malapira T" first="Teresita" last="Malapira">Teresita Malapira</name><affiliation><mods:affiliation>Parkinson's Disease and Movement Disorders Center, University of South Florida, Tampa, FL</mods:affiliation></affiliation></author><author><name sortKey="Smith, Donald" sort="Smith, Donald" uniqKey="Smith D" first="Donald" last="Smith">Donald Smith</name><affiliation><mods:affiliation>Division of Neurosurgery, University of South Florida, Tampa, FL</mods:affiliation></affiliation></author><author><name sortKey="Tarsy, Daniel" sort="Tarsy, Daniel" uniqKey="Tarsy D" first="Daniel" last="Tarsy">Daniel Tarsy</name><affiliation><mods:affiliation>Beth Israel–Deaconess Hospital Harvard Medical School, Boston, MA</mods:affiliation></affiliation></author><author><name sortKey="Miyawaki, Edison" sort="Miyawaki, Edison" uniqKey="Miyawaki E" first="Edison" last="Miyawaki">Edison Miyawaki</name><affiliation><mods:affiliation>Beth Israel–Deaconess Hospital Harvard Medical School, Boston, MA</mods:affiliation></affiliation></author><author><name sortKey="Norregaard, Thorkild" sort="Norregaard, Thorkild" uniqKey="Norregaard T" first="Thorkild" last="Norregaard">Thorkild Norregaard</name><affiliation><mods:affiliation>Department of Neurology, Harvard Medical School, Boston, MA</mods:affiliation></affiliation></author><author><name sortKey="Kormos, Theresa" sort="Kormos, Theresa" uniqKey="Kormos T" first="Theresa" last="Kormos">Theresa Kormos</name><affiliation><mods:affiliation>Beth Israel–Deaconess Hospital Harvard Medical School, Boston, MA</mods:affiliation></affiliation></author><author><name sortKey="Olanow, C Warren" sort="Olanow, C Warren" uniqKey="Olanow C" first="C. Warren" last="Olanow">C. Warren Olanow</name><affiliation><mods:affiliation>Department of Neurology, Mt Sinai Medical Center, New York, NY</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:E5B0F830BCD310C2722E4D0B8B1006F0B142C8E4</idno><date when="1997" year="1997">1997</date><idno type="doi">10.1002/ana.410420304</idno><idno type="url">https://api.istex.fr/document/E5B0F830BCD310C2722E4D0B8B1006F0B142C8E4/fulltext/pdf</idno><idno type="wicri:Area/Main/Corpus">001015</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">High‐frequency unilateral thalamic stimulation in the treatment of essential and parkinsonian tremor</title><author><name sortKey="Koller" sort="Koller" uniqKey="Koller" last="Koller">Koller</name><affiliation><mods:affiliation>Department of Neurology, University of Kansas Medical Center, Kansas City, KS</mods:affiliation></affiliation></author><author><name sortKey="Pahwa, Rajesh" sort="Pahwa, Rajesh" uniqKey="Pahwa R" first="Rajesh" last="Pahwa">Rajesh Pahwa</name><affiliation><mods:affiliation>Department of Neurology, University of Kansas Medical Center, Kansas City, KS</mods:affiliation></affiliation></author><author><name sortKey="Busenbark, Karen" sort="Busenbark, Karen" uniqKey="Busenbark K" first="Karen" last="Busenbark">Karen Busenbark</name><affiliation><mods:affiliation>Department of Neurology, University of Kansas Medical Center, Kansas City, KS</mods:affiliation></affiliation></author><author><name sortKey="Hubble, Jean" sort="Hubble, Jean" uniqKey="Hubble J" first="Jean" last="Hubble">Jean Hubble</name><affiliation><mods:affiliation>Department of Neurology, Ohio State University Hospitals, Columbus, OH</mods:affiliation></affiliation></author><author><name sortKey="Wilkinson, Steve" sort="Wilkinson, Steve" uniqKey="Wilkinson S" first="Steve" last="Wilkinson">Steve Wilkinson</name><affiliation><mods:affiliation>Department of Neurosurgery, University of Kansas Medical Center, Kansas City, KS</mods:affiliation></affiliation></author><author><name sortKey="Lang, Anthony" sort="Lang, Anthony" uniqKey="Lang A" first="Anthony" last="Lang">Anthony Lang</name><affiliation><mods:affiliation>Division of Neurology, Toronto Hospital, Toronto, Ontario, Canada</mods:affiliation></affiliation></author><author><name sortKey="Tuite, Paul" sort="Tuite, Paul" uniqKey="Tuite P" first="Paul" last="Tuite">Paul Tuite</name><affiliation><mods:affiliation>Division of Neurology, Toronto Hospital, Toronto, Ontario, Canada</mods:affiliation></affiliation></author><author><name sortKey="Sime, Elspeth" sort="Sime, Elspeth" uniqKey="Sime E" first="Elspeth" last="Sime">Elspeth Sime</name><affiliation><mods:affiliation>Division of Neurology, Toronto Hospital, Toronto, Ontario, Canada</mods:affiliation></affiliation></author><author><name sortKey="Lazano, Andres" sort="Lazano, Andres" uniqKey="Lazano A" first="Andres" last="Lazano">Andres Lazano</name><affiliation><mods:affiliation>Division of Neurosurgery, Toronto Hospital, Toronto, Ontario, Canada</mods:affiliation></affiliation></author><author><name sortKey="Hauser, Robert" sort="Hauser, Robert" uniqKey="Hauser R" first="Robert" last="Hauser">Robert Hauser</name><affiliation><mods:affiliation>Parkinson's Disease and Movement Disorders Center, University of South Florida, Tampa, FL</mods:affiliation></affiliation></author><author><name sortKey="Malapira, Teresita" sort="Malapira, Teresita" uniqKey="Malapira T" first="Teresita" last="Malapira">Teresita Malapira</name><affiliation><mods:affiliation>Parkinson's Disease and Movement Disorders Center, University of South Florida, Tampa, FL</mods:affiliation></affiliation></author><author><name sortKey="Smith, Donald" sort="Smith, Donald" uniqKey="Smith D" first="Donald" last="Smith">Donald Smith</name><affiliation><mods:affiliation>Division of Neurosurgery, University of South Florida, Tampa, FL</mods:affiliation></affiliation></author><author><name sortKey="Tarsy, Daniel" sort="Tarsy, Daniel" uniqKey="Tarsy D" first="Daniel" last="Tarsy">Daniel Tarsy</name><affiliation><mods:affiliation>Beth Israel–Deaconess Hospital Harvard Medical School, Boston, MA</mods:affiliation></affiliation></author><author><name sortKey="Miyawaki, Edison" sort="Miyawaki, Edison" uniqKey="Miyawaki E" first="Edison" last="Miyawaki">Edison Miyawaki</name><affiliation><mods:affiliation>Beth Israel–Deaconess Hospital Harvard Medical School, Boston, MA</mods:affiliation></affiliation></author><author><name sortKey="Norregaard, Thorkild" sort="Norregaard, Thorkild" uniqKey="Norregaard T" first="Thorkild" last="Norregaard">Thorkild Norregaard</name><affiliation><mods:affiliation>Department of Neurology, Harvard Medical School, Boston, MA</mods:affiliation></affiliation></author><author><name sortKey="Kormos, Theresa" sort="Kormos, Theresa" uniqKey="Kormos T" first="Theresa" last="Kormos">Theresa Kormos</name><affiliation><mods:affiliation>Beth Israel–Deaconess Hospital Harvard Medical School, Boston, MA</mods:affiliation></affiliation></author><author><name sortKey="Olanow, C Warren" sort="Olanow, C Warren" uniqKey="Olanow C" first="C. Warren" last="Olanow">C. Warren Olanow</name><affiliation><mods:affiliation>Department of Neurology, Mt Sinai Medical Center, New York, NY</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Annals of Neurology</title><title level="j" type="sub">Official Journal of the American Neurological Association and the Child Neurology Society</title><title level="j" type="abbrev">Ann Neurol.</title><idno type="ISSN">0364-5134</idno><idno type="eISSN">1531-8249</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="1997-09">1997-09</date><biblScope unit="volume">42</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="292">292</biblScope><biblScope unit="page" to="299">299</biblScope></imprint><idno type="ISSN">0364-5134</idno></series><idno type="istex">E5B0F830BCD310C2722E4D0B8B1006F0B142C8E4</idno><idno type="DOI">10.1002/ana.410420304</idno><idno type="ArticleID">ANA410420304</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0364-5134</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Pharmacologic treatment for essential tremor and the tremor of Parkinson's disease is often inadequate. Stereotaxic surgery, such as thalamotomy, can effectively reduce tremors. We performed a multicenter trial of unilateral high‐frequency stimulation of the ventral intermedius nucleus of the thalamus in 29 patients with essential tremor and 24 patients with Parkinson's disease, using a blinded assessment at 3 months after surgery to compare clinical rating of tremor with stimulation ON with stimulation OFF and baseline and a 1‐year follow‐up. Six patients were not implanted because of lack of intraoperative tremor suppression (2 patients), hemorrhage (2 patients), withdrawal of consent (1 patient), and persistent microthalamotomy effect (1 patient). A significant reduction in both essential and parkinsonian tremor occurred contralaterally with stimulation. Patients reported a significant reduction in disability. Measures of function were significantly improved in patients with essential tremor. Complications related to surgery in implanted patients were few. Stimulation was commonly associated with transient paresthesias. Other adverse effects were mild and well tolerated. Efficacy was not reduced at 1 year. Chronic high‐frequency stimulation is safe and highly effective in ameliorating essential and parkinsonian tremor.</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>Dr. Koller PhD., MD</name><affiliations><json:string>Department of Neurology, University of Kansas Medical Center, Kansas City, KS</json:string></affiliations></json:item><json:item><name>Rajesh Pahwa MD</name><affiliations><json:string>Department of Neurology, University of Kansas Medical Center, Kansas City, KS</json:string></affiliations></json:item><json:item><name>Karen Busenbark BSN</name><affiliations><json:string>Department of Neurology, University of Kansas Medical Center, Kansas City, KS</json:string></affiliations></json:item><json:item><name>Jean Hubble MD</name><affiliations><json:string>Department of Neurology, Ohio State University Hospitals, Columbus, OH</json:string></affiliations></json:item><json:item><name>Steve Wilkinson MD</name><affiliations><json:string>Department of Neurosurgery, University of Kansas Medical Center, Kansas City, KS</json:string></affiliations></json:item><json:item><name>Anthony Lang MD</name><affiliations><json:string>Division of Neurology, Toronto Hospital, Toronto, Ontario, Canada</json:string></affiliations></json:item><json:item><name>Paul Tuite MD</name><affiliations><json:string>Division of Neurology, Toronto Hospital, Toronto, Ontario, Canada</json:string></affiliations></json:item><json:item><name>Elspeth Sime RN</name><affiliations><json:string>Division of Neurology, Toronto Hospital, Toronto, Ontario, Canada</json:string></affiliations></json:item><json:item><name>Andres Lazano MD</name><affiliations><json:string>Division of Neurosurgery, Toronto Hospital, Toronto, Ontario, Canada</json:string></affiliations></json:item><json:item><name>Robert Hauser MD</name><affiliations><json:string>Parkinson's Disease and Movement Disorders Center, University of South Florida, Tampa, FL</json:string></affiliations></json:item><json:item><name>Teresita Malapira BSN</name><affiliations><json:string>Parkinson's Disease and Movement Disorders Center, University of South Florida, Tampa, FL</json:string></affiliations></json:item><json:item><name>Donald Smith MD</name><affiliations><json:string>Division of Neurosurgery, University of South Florida, Tampa, FL</json:string></affiliations></json:item><json:item><name>Daniel Tarsy MD</name><affiliations><json:string>Beth Israel–Deaconess Hospital Harvard Medical School, Boston, MA</json:string></affiliations></json:item><json:item><name>Edison Miyawaki MD</name><affiliations><json:string>Beth Israel–Deaconess Hospital Harvard Medical School, Boston, MA</json:string></affiliations></json:item><json:item><name>Thorkild Norregaard MD</name><affiliations><json:string>Department of Neurology, Harvard Medical School, Boston, MA</json:string></affiliations></json:item><json:item><name>Theresa Kormos MSN</name><affiliations><json:string>Beth Israel–Deaconess Hospital Harvard Medical School, Boston, MA</json:string></affiliations></json:item><json:item><name>C. Warren Olanow MD</name><affiliations><json:string>Department of Neurology, Mt Sinai Medical Center, New York, NY</json:string></affiliations></json:item></author><articleId><json:string>ANA410420304</json:string></articleId><language><json:string>eng</json:string></language><abstract>Pharmacologic treatment for essential tremor and the tremor of Parkinson's disease is often inadequate. Stereotaxic surgery, such as thalamotomy, can effectively reduce tremors. We performed a multicenter trial of unilateral high‐frequency stimulation of the ventral intermedius nucleus of the thalamus in 29 patients with essential tremor and 24 patients with Parkinson's disease, using a blinded assessment at 3 months after surgery to compare clinical rating of tremor with stimulation ON with stimulation OFF and baseline and a 1‐year follow‐up. Six patients were not implanted because of lack of intraoperative tremor suppression (2 patients), hemorrhage (2 patients), withdrawal of consent (1 patient), and persistent microthalamotomy effect (1 patient). A significant reduction in both essential and parkinsonian tremor occurred contralaterally with stimulation. Patients reported a significant reduction in disability. Measures of function were significantly improved in patients with essential tremor. Complications related to surgery in implanted patients were few. Stimulation was commonly associated with transient paresthesias. Other adverse effects were mild and well tolerated. Efficacy was not reduced at 1 year. Chronic high‐frequency stimulation is safe and highly effective in ameliorating essential and parkinsonian tremor.</abstract><qualityIndicators><score>7.084</score><pdfVersion>1.3</pdfVersion><pdfPageSize>576 x 792 pts</pdfPageSize><refBibsNative>true</refBibsNative><keywordCount>0</keywordCount><abstractCharCount>1343</abstractCharCount><pdfWordCount>4888</pdfWordCount><pdfCharCount>30082</pdfCharCount><pdfPageCount>8</pdfPageCount><abstractWordCount>183</abstractWordCount></qualityIndicators><title>High‐frequency unilateral thalamic stimulation in the treatment of essential and parkinsonian tremor</title><genre><json:string>article</json:string></genre><host><volume>42</volume><publisherId><json:string>ANA</json:string></publisherId><pages><total>8</total><last>299</last><first>292</first></pages><issn><json:string>0364-5134</json:string></issn><issue>3</issue><subject><json:item><value>Original 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uri="https://api.istex.fr/document/E5B0F830BCD310C2722E4D0B8B1006F0B142C8E4/fulltext/tei"><teiHeader><fileDesc><titleStmt><title level="a" type="main" xml:lang="en">High‐frequency unilateral thalamic stimulation in the treatment of essential and parkinsonian tremor</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><availability><p>WILEY</p></availability><date>1997</date></publicationStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="en">High‐frequency unilateral thalamic stimulation in the treatment of essential and parkinsonian tremor</title><author><persName><surname>Koller</surname></persName><roleName type="degree">Dr.</roleName><note type="correspondence"><p>Correspondence: Department of Neurology, University of Kansas Medical Center, 3901 Rainbow Blvd, Kansas City, KS 66160‐7314</p></note><affiliation>Department of Neurology, University of Kansas Medical Center, Kansas City, KS</affiliation></author><author><persName><forename type="first">Rajesh</forename><surname>Pahwa</surname></persName><roleName type="degree">MD</roleName><affiliation>Department of Neurology, University of Kansas Medical Center, Kansas City, KS</affiliation></author><author><persName><forename type="first">Karen</forename><surname>Busenbark</surname></persName><roleName type="degree">BSN</roleName><affiliation>Department of Neurology, University of Kansas Medical Center, Kansas City, KS</affiliation></author><author><persName><forename type="first">Jean</forename><surname>Hubble</surname></persName><roleName type="degree">MD</roleName><affiliation>Department of Neurology, Ohio State University Hospitals, Columbus, OH</affiliation></author><author><persName><forename type="first">Steve</forename><surname>Wilkinson</surname></persName><roleName type="degree">MD</roleName><affiliation>Department of Neurosurgery, University of Kansas Medical Center, Kansas City, KS</affiliation></author><author><persName><forename type="first">Anthony</forename><surname>Lang</surname></persName><roleName type="degree">MD</roleName><affiliation>Division of Neurology, Toronto Hospital, Toronto, Ontario, Canada</affiliation></author><author><persName><forename type="first">Paul</forename><surname>Tuite</surname></persName><roleName type="degree">MD</roleName><affiliation>Division of Neurology, Toronto Hospital, Toronto, Ontario, Canada</affiliation></author><author><persName><forename type="first">Elspeth</forename><surname>Sime</surname></persName><roleName type="degree">RN</roleName><affiliation>Division of Neurology, Toronto Hospital, Toronto, Ontario, Canada</affiliation></author><author><persName><forename type="first">Andres</forename><surname>Lazano</surname></persName><roleName type="degree">MD</roleName><affiliation>Division of Neurosurgery, Toronto Hospital, Toronto, Ontario, Canada</affiliation></author><author><persName><forename type="first">Robert</forename><surname>Hauser</surname></persName><roleName type="degree">MD</roleName><affiliation>Parkinson's Disease and Movement Disorders Center, University of South Florida, Tampa, FL</affiliation></author><author><persName><forename type="first">Teresita</forename><surname>Malapira</surname></persName><roleName type="degree">BSN</roleName><affiliation>Parkinson's Disease and Movement Disorders Center, University of South Florida, Tampa, FL</affiliation></author><author><persName><forename type="first">Donald</forename><surname>Smith</surname></persName><roleName type="degree">MD</roleName><affiliation>Division of Neurosurgery, University of South Florida, Tampa, FL</affiliation></author><author><persName><forename type="first">Daniel</forename><surname>Tarsy</surname></persName><roleName type="degree">MD</roleName><affiliation>Beth Israel–Deaconess Hospital Harvard Medical School, Boston, MA</affiliation></author><author><persName><forename type="first">Edison</forename><surname>Miyawaki</surname></persName><roleName type="degree">MD</roleName><affiliation>Beth Israel–Deaconess Hospital Harvard Medical School, Boston, MA</affiliation></author><author><persName><forename type="first">Thorkild</forename><surname>Norregaard</surname></persName><roleName type="degree">MD</roleName><affiliation>Department of Neurology, Harvard Medical School, Boston, MA</affiliation></author><author><persName><forename type="first">Theresa</forename><surname>Kormos</surname></persName><roleName type="degree">MSN</roleName><affiliation>Beth Israel–Deaconess Hospital Harvard Medical School, Boston, MA</affiliation></author><author><persName><forename type="first">C. Warren</forename><surname>Olanow</surname></persName><roleName type="degree">MD</roleName><affiliation>Department of Neurology, Mt Sinai Medical Center, New York, NY</affiliation></author></analytic><monogr><title level="j">Annals of Neurology</title><title level="j" type="sub">Official Journal of the American Neurological Association and the Child Neurology Society</title><title level="j" type="abbrev">Ann Neurol.</title><idno type="pISSN">0364-5134</idno><idno type="eISSN">1531-8249</idno><idno type="DOI">10.1002/(ISSN)1531-8249</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="1997-09"></date><biblScope unit="volume">42</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="292">292</biblScope><biblScope unit="page" to="299">299</biblScope></imprint></monogr><idno type="istex">E5B0F830BCD310C2722E4D0B8B1006F0B142C8E4</idno><idno type="DOI">10.1002/ana.410420304</idno><idno type="ArticleID">ANA410420304</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>1997</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>Pharmacologic treatment for essential tremor and the tremor of Parkinson's disease is often inadequate. Stereotaxic surgery, such as thalamotomy, can effectively reduce tremors. We performed a multicenter trial of unilateral high‐frequency stimulation of the ventral intermedius nucleus of the thalamus in 29 patients with essential tremor and 24 patients with Parkinson's disease, using a blinded assessment at 3 months after surgery to compare clinical rating of tremor with stimulation ON with stimulation OFF and baseline and a 1‐year follow‐up. Six patients were not implanted because of lack of intraoperative tremor suppression (2 patients), hemorrhage (2 patients), withdrawal of consent (1 patient), and persistent microthalamotomy effect (1 patient). A significant reduction in both essential and parkinsonian tremor occurred contralaterally with stimulation. Patients reported a significant reduction in disability. Measures of function were significantly improved in patients with essential tremor. Complications related to surgery in implanted patients were few. Stimulation was commonly associated with transient paresthesias. Other adverse effects were mild and well tolerated. Efficacy was not reduced at 1 year. Chronic high‐frequency stimulation is safe and highly effective in ameliorating essential and parkinsonian tremor.</p></abstract><textClass><keywords scheme="Journal Subject"><list><head>article category</head><item><term>Original Article</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="1996-08-16">Received</change><change when="1997-02-25">Registration</change><change when="1997-09">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><original>false</original><mimetype>text/plain</mimetype><extension>txt</extension><uri>https://api.istex.fr/document/E5B0F830BCD310C2722E4D0B8B1006F0B142C8E4/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Wiley Subscription Services, Inc., A Wiley Company</publisherName><publisherLoc>Hoboken</publisherLoc></publisherInfo><doi registered="yes">10.1002/(ISSN)1531-8249</doi><issn type="print">0364-5134</issn><issn type="electronic">1531-8249</issn><idGroup><id type="product" value="ANA"></id></idGroup><titleGroup><title type="main" xml:lang="en" sort="ANNALS OF NEUROLOGY">Annals of Neurology</title><title type="subtitle">Official Journal of the American Neurological Association and the Child Neurology Society</title><title type="short">Ann Neurol.</title></titleGroup></publicationMeta><publicationMeta level="part" position="30"><doi origin="wiley" registered="yes">10.1002/ana.v42:3</doi><numberingGroup><numbering type="journalVolume" number="42">42</numbering><numbering type="journalIssue">3</numbering></numberingGroup><coverDate startDate="1997-09">September 1997</coverDate></publicationMeta><publicationMeta level="unit" type="article" position="4" status="forIssue"><doi origin="wiley" registered="yes">10.1002/ana.410420304</doi><idGroup><id type="unit" value="ANA410420304"></id></idGroup><countGroup><count type="pageTotal" number="8"></count></countGroup><titleGroup><title type="articleCategory">Original Article</title><title type="tocHeading1">Original Articles</title></titleGroup><copyright ownership="thirdParty">Copyright © 1997 the American Neurological Association</copyright><eventGroup><event type="manuscriptReceived" date="1996-08-16"></event><event type="manuscriptRevised" date="1997-02-25"></event><event type="manuscriptAccepted" date="1997-02-25"></event><event type="firstOnline" date="2004-10-08"></event><event type="publishedOnlineFinalForm" date="2004-10-08"></event><event type="xmlConverted" agent="Converter:JWSART34_TO_WML3G version:2.3.1 mode:FullText source:HeaderRef result:HeaderRef" date="2010-02-23"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:3.8.8" date="2014-01-03"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.1.7 mode:FullText,remove_FC" date="2014-10-14"></event></eventGroup><numberingGroup><numbering type="pageFirst">292</numbering><numbering type="pageLast">299</numbering></numberingGroup><correspondenceTo>Department of Neurology, University of Kansas Medical Center, 3901 Rainbow Blvd, Kansas City, KS 66160‐7314</correspondenceTo><linkGroup><link type="toTypesetVersion" href="file:ANA.ANA410420304.pdf"></link></linkGroup></publicationMeta><contentMeta><countGroup><count type="figureTotal" number="2"></count><count type="tableTotal" number="4"></count><count type="referenceTotal" number="27"></count></countGroup><titleGroup><title type="main" xml:lang="en">High‐frequency unilateral thalamic stimulation in the treatment of essential and parkinsonian tremor</title><title type="short" xml:lang="en">Deep Brain Stimulation and Tremor</title></titleGroup><creators><creator xml:id="au1" creatorRole="author" affiliationRef="#af1" corresponding="yes"><personName><honorifics>Dr.</honorifics><givenNames>William</givenNames><familyName>Koller</familyName><degrees>PhD., MD</degrees></personName></creator><creator xml:id="au2" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Rajesh</givenNames><familyName>Pahwa</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au3" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Karen</givenNames><familyName>Busenbark</familyName><degrees>BSN</degrees></personName></creator><creator xml:id="au4" creatorRole="author" affiliationRef="#af3"><personName><givenNames>Jean</givenNames><familyName>Hubble</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au5" creatorRole="author" affiliationRef="#af2"><personName><givenNames>Steve</givenNames><familyName>Wilkinson</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au6" creatorRole="author" affiliationRef="#af9"><personName><givenNames>Anthony</givenNames><familyName>Lang</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au7" creatorRole="author" affiliationRef="#af9"><personName><givenNames>Paul</givenNames><familyName>Tuite</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au8" creatorRole="author" affiliationRef="#af9"><personName><givenNames>Elspeth</givenNames><familyName>Sime</familyName><degrees>RN</degrees></personName></creator><creator xml:id="au9" creatorRole="author" affiliationRef="#af10"><personName><givenNames>Andres</givenNames><familyName>Lazano</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au10" creatorRole="author" affiliationRef="#af4"><personName><givenNames>Robert</givenNames><familyName>Hauser</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au11" creatorRole="author" affiliationRef="#af4"><personName><givenNames>Teresita</givenNames><familyName>Malapira</familyName><degrees>BSN</degrees></personName></creator><creator xml:id="au12" creatorRole="author" affiliationRef="#af5"><personName><givenNames>Donald</givenNames><familyName>Smith</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au13" creatorRole="author" affiliationRef="#af6"><personName><givenNames>Daniel</givenNames><familyName>Tarsy</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au14" creatorRole="author" affiliationRef="#af6"><personName><givenNames>Edison</givenNames><familyName>Miyawaki</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au15" creatorRole="author" affiliationRef="#af7"><personName><givenNames>Thorkild</givenNames><familyName>Norregaard</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au16" creatorRole="author" affiliationRef="#af6"><personName><givenNames>Theresa</givenNames><familyName>Kormos</familyName><degrees>MSN</degrees></personName></creator><creator xml:id="au17" creatorRole="author" affiliationRef="#af8"><personName><givenNames>C. Warren</givenNames><familyName>Olanow</familyName><degrees>MD</degrees></personName></creator></creators><affiliationGroup><affiliation xml:id="af1" countryCode="US" type="organization"><unparsedAffiliation>Department of Neurology, University of Kansas Medical Center, Kansas City, KS</unparsedAffiliation></affiliation><affiliation xml:id="af2" countryCode="US" type="organization"><unparsedAffiliation>Department of Neurosurgery, University of Kansas Medical Center, Kansas City, KS</unparsedAffiliation></affiliation><affiliation xml:id="af3" countryCode="US" type="organization"><unparsedAffiliation>Department of Neurology, Ohio State University Hospitals, Columbus, OH</unparsedAffiliation></affiliation><affiliation xml:id="af4" countryCode="US" type="organization"><unparsedAffiliation>Parkinson's Disease and Movement Disorders Center, University of South Florida, Tampa, FL</unparsedAffiliation></affiliation><affiliation xml:id="af5" countryCode="US" type="organization"><unparsedAffiliation>Division of Neurosurgery, University of South Florida, Tampa, FL</unparsedAffiliation></affiliation><affiliation xml:id="af6" countryCode="US" type="organization"><unparsedAffiliation>Beth Israel–Deaconess Hospital Harvard Medical School, Boston, MA</unparsedAffiliation></affiliation><affiliation xml:id="af7" countryCode="US" type="organization"><unparsedAffiliation>Department of Neurology, Harvard Medical School, Boston, MA</unparsedAffiliation></affiliation><affiliation xml:id="af8" countryCode="US" type="organization"><unparsedAffiliation>Department of Neurology, Mt Sinai Medical Center, New York, NY</unparsedAffiliation></affiliation><affiliation xml:id="af9" countryCode="CA" type="organization"><unparsedAffiliation>Division of Neurology, Toronto Hospital, Toronto, Ontario, Canada</unparsedAffiliation></affiliation><affiliation xml:id="af10" countryCode="CA" type="organization"><unparsedAffiliation>Division of Neurosurgery, Toronto Hospital, Toronto, Ontario, Canada</unparsedAffiliation></affiliation></affiliationGroup><abstractGroup><abstract type="main" xml:lang="en"><title type="main">Abstract</title><p>Pharmacologic treatment for essential tremor and the tremor of Parkinson's disease is often inadequate. Stereotaxic surgery, such as thalamotomy, can effectively reduce tremors. We performed a multicenter trial of unilateral high‐frequency stimulation of the ventral intermedius nucleus of the thalamus in 29 patients with essential tremor and 24 patients with Parkinson's disease, using a blinded assessment at 3 months after surgery to compare clinical rating of tremor with stimulation ON with stimulation OFF and baseline and a 1‐year follow‐up. Six patients were not implanted because of lack of intraoperative tremor suppression (2 patients), hemorrhage (2 patients), withdrawal of consent (1 patient), and persistent microthalamotomy effect (1 patient). A significant reduction in both essential and parkinsonian tremor occurred contralaterally with stimulation. Patients reported a significant reduction in disability. Measures of function were significantly improved in patients with essential tremor. Complications related to surgery in implanted patients were few. Stimulation was commonly associated with transient paresthesias. Other adverse effects were mild and well tolerated. Efficacy was not reduced at 1 year. Chronic high‐frequency stimulation is safe and highly effective in ameliorating essential and parkinsonian tremor.</p></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>High‐frequency unilateral thalamic stimulation in the treatment of essential and parkinsonian tremor</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>Deep Brain Stimulation and Tremor</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>High‐frequency unilateral thalamic stimulation in the treatment of essential and parkinsonian tremor</title></titleInfo><name type="personal"><namePart type="termsOfAddress">Dr.</namePart><namePart type="family">Koller</namePart><namePart type="termsOfAddress">PhD., MD</namePart><affiliation>Department of Neurology, University of Kansas Medical Center, Kansas City, KS</affiliation><description>Correspondence: Department of Neurology, University of Kansas Medical Center, 3901 Rainbow Blvd, Kansas City, KS 66160‐7314</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Rajesh</namePart><namePart type="family">Pahwa</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurology, University of Kansas Medical Center, Kansas City, KS</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Karen</namePart><namePart type="family">Busenbark</namePart><namePart type="termsOfAddress">BSN</namePart><affiliation>Department of Neurology, University of Kansas Medical Center, Kansas City, KS</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Jean</namePart><namePart type="family">Hubble</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurology, Ohio State University Hospitals, Columbus, OH</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Steve</namePart><namePart type="family">Wilkinson</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurosurgery, University of Kansas Medical Center, Kansas City, KS</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Anthony</namePart><namePart type="family">Lang</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Division of Neurology, Toronto Hospital, Toronto, Ontario, Canada</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Paul</namePart><namePart type="family">Tuite</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Division of Neurology, Toronto Hospital, Toronto, Ontario, Canada</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Elspeth</namePart><namePart type="family">Sime</namePart><namePart type="termsOfAddress">RN</namePart><affiliation>Division of Neurology, Toronto Hospital, Toronto, Ontario, Canada</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Andres</namePart><namePart type="family">Lazano</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Division of Neurosurgery, Toronto Hospital, Toronto, Ontario, Canada</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Robert</namePart><namePart type="family">Hauser</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Parkinson's Disease and Movement Disorders Center, University of South Florida, Tampa, FL</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Teresita</namePart><namePart type="family">Malapira</namePart><namePart type="termsOfAddress">BSN</namePart><affiliation>Parkinson's Disease and Movement Disorders Center, University of South Florida, Tampa, FL</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Donald</namePart><namePart type="family">Smith</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Division of Neurosurgery, University of South Florida, Tampa, FL</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Daniel</namePart><namePart type="family">Tarsy</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Beth Israel–Deaconess Hospital Harvard Medical School, Boston, MA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Edison</namePart><namePart type="family">Miyawaki</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Beth Israel–Deaconess Hospital Harvard Medical School, Boston, MA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Thorkild</namePart><namePart type="family">Norregaard</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurology, Harvard Medical School, Boston, MA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Theresa</namePart><namePart type="family">Kormos</namePart><namePart type="termsOfAddress">MSN</namePart><affiliation>Beth Israel–Deaconess Hospital Harvard Medical School, Boston, MA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C. Warren</namePart><namePart type="family">Olanow</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurology, Mt Sinai Medical Center, New York, NY</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article"></genre><originInfo><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><place><placeTerm type="text">Hoboken</placeTerm></place><dateIssued encoding="w3cdtf">1997-09</dateIssued><dateCaptured encoding="w3cdtf">1996-08-16</dateCaptured><dateValid encoding="w3cdtf">1997-02-25</dateValid><copyrightDate encoding="w3cdtf">1997</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="figures">2</extent><extent unit="tables">4</extent><extent unit="references">27</extent></physicalDescription><abstract lang="en">Pharmacologic treatment for essential tremor and the tremor of Parkinson's disease is often inadequate. Stereotaxic surgery, such as thalamotomy, can effectively reduce tremors. We performed a multicenter trial of unilateral high‐frequency stimulation of the ventral intermedius nucleus of the thalamus in 29 patients with essential tremor and 24 patients with Parkinson's disease, using a blinded assessment at 3 months after surgery to compare clinical rating of tremor with stimulation ON with stimulation OFF and baseline and a 1‐year follow‐up. Six patients were not implanted because of lack of intraoperative tremor suppression (2 patients), hemorrhage (2 patients), withdrawal of consent (1 patient), and persistent microthalamotomy effect (1 patient). A significant reduction in both essential and parkinsonian tremor occurred contralaterally with stimulation. Patients reported a significant reduction in disability. Measures of function were significantly improved in patients with essential tremor. Complications related to surgery in implanted patients were few. Stimulation was commonly associated with transient paresthesias. Other adverse effects were mild and well tolerated. Efficacy was not reduced at 1 year. Chronic high‐frequency stimulation is safe and highly effective in ameliorating essential and parkinsonian tremor.</abstract><relatedItem type="host"><titleInfo><title>Annals of Neurology</title><subTitle>Official Journal of the American Neurological Association and the Child Neurology Society</subTitle></titleInfo><titleInfo type="abbreviated"><title>Ann Neurol.</title></titleInfo><genre type="Journal">journal</genre><subject><genre>article category</genre><topic>Original Article</topic></subject><identifier type="ISSN">0364-5134</identifier><identifier type="eISSN">1531-8249</identifier><identifier type="DOI">10.1002/(ISSN)1531-8249</identifier><identifier type="PublisherID">ANA</identifier><part><date>1997</date><detail type="volume"><caption>vol.</caption><number>42</number></detail><detail type="issue"><caption>no.</caption><number>3</number></detail><extent unit="pages"><start>292</start><end>299</end><total>8</total></extent></part></relatedItem><identifier type="istex">E5B0F830BCD310C2722E4D0B8B1006F0B142C8E4</identifier><identifier type="DOI">10.1002/ana.410420304</identifier><identifier type="ArticleID">ANA410420304</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright © 1997 the American Neurological Association</accessCondition><recordInfo><recordContentSource>WILEY</recordContentSource><recordOrigin>Wiley Subscription Services, Inc., A Wiley Company</recordOrigin></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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